Does the Timing of Source Control in Sepsis Make a Difference?


The emergency department resuscitation of patients with sepsis focuses on early recognition, timely administration of appropriate antibiotics, appropriate fluid resuscitation, early vasopressor initiation for patients with sepsis-induced hypoperfusion, and hemodynamic monitoring.  Source control is also an important component in the resuscitation of patients with sepsis.  Though current guidelines identify source control as a “best practice” the optimal timing of source control remains uncertain.  In this podcast, we discuss a recent study that evaluated the timing of source control with mortality in patients with community-acquired sepsis.