High-Flow or Standard O2 for Hypoxemic Respiratory Failure?

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Acute hypoxemic respiratory failure is a leading cause of ICU admission worldwide.  Oxygen is first-line therapy for patients with acute hypoxemic respiratory failure and can be given via nasal cannula (NC), non-rebreather mask (NRB), high-flow nasal cannula (HFNC), or noninvasive ventilation (NIV). At present, the literature is inconsistent on which mode of oxygen therapy reduces mortality.  In this podcast, we …

Should We Use NIPPV For Asthma?

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Nearly 200,000 patients are admitted to the hospital each year in the United States for acute asthma exacerbations.  Approximately 2% of patients are intubated and placed on mechanical ventilation. In-hospital mortality is nearly 100 times higher when a patient with acute asthma exacerbation is intubated.  Non-invasive positive pressure ventilation is well known to improve outcomes for patients with an acute …

Caring for the Patient with ROSC

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More than 600,000 patients in North America sustain sudden cardiac arrest each year.  When return of spontaneous circulation (ROSC) is achieved, there are a number of critical interventions to consider in order to provide the patient with the best chance of being discharged with meaningful neurologic survival.  In this podcast, we discuss an excellent recent review article on the management …

Critical Issues in ED Intubation

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Emergency physicians intubate critically ill patients daily.  Unfortunately, up to 17% of ED intubations can be complicated by peri-intubation hypoxemia, hypotension, and cardiac arrest. Efforts to optimize patient’s physiology prior to rapid sequence intubation are critical in mitigating the risk of potentially disastrous peri-intubation complications.  In this podcast, we discuss a recent Clinical Policy from the American College of Emergency …

Conservative Oxygen Therapy for Ventilated ICU Patients?

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Oxygen is one of the most used, and misused, therapies delivered to critically ill patients.  In recent years, a number of trials have compared the use of a conservative oxygen therapy strategy with a liberal oxygen therapy strategy.  These trials have produced mixed results and the optimal oxygen strategy for critically ill patients remains unknown.  In this podcast, we discuss …

Dexmedetomidine or Propofol for Sedation in the Critically Ill?

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Critically ill patients receiving mechanical ventilation require analgesia and sedation.  At present, propofol remains the most widely used sedative for intubated/ventilated patients.  Recent trials have suggested that dexmedetomidine may reduce delirium and the duration of mechanical ventilation compared with other sedative medications.  In fact, recent SCCM guidelines suggest the use of dexmedetomidine over propofol in intubated patients.  In this podcast, …

When Should We Start Vasopressin in Septic Shock?

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Sepsis results in more than 250,000 deaths each year in the United States. Resuscitation of the septic patient centers on timely recognition, early antibiotic administration, appropriate fluid administration, source control, and vasopressor administration for those with inadequate mean arterial pressures. At present, norepinephrine is the recommended first-line vasopressor for sepsis.  Current guidelines then recommend vasopressin as the second-line vasopressor agent, …