Approximately 2 million adult patients undergo intubation in the United States each year. Hypotension and cardiovascular collapse may occur in up to 40% of critically ill patients in the ICU who undergo intubation. Guidelines and expert recommendations often suggest the administration of IVFs during RSI to prevent cardiovascular collapse. However, a recent trial found that an IVF bolus during induction did not prevent cardiovascular collapse in a population of critically ill patients. In this podcast, we review and discuss the recently published PREPARE II Trial, which evaluated the administration of IVFs to prevent cardiovascular collapse in critically ill patients undergoing intubation and who were receiving positive pressure ventilation.