Vitamin C for Septic Shock?

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In 2017, Paul Marik published a single-center retrospective before-and-after study that demonstrated significant mortality benefit to patients with septic shock who received a cocktail of steroids, vitamin C, and hydrocortisone.  Since that time, many providers have adopted this cocktail for the treatment of septic shock, despite the fact that no randomized trial has evaluated this regimen.  In this podcast, we …

COVID-19 Update – March 2020

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In December 2019 a novel coronavirus (now named COVID-19) was identified as responsible for a cluster of pneumonia cases in Wuhan, China. As of March 2020, over 50 countries have identified patients who have tested (+) for COVID-19, with over 90,000 identified cases and more than 3000 deaths to date. As the discussion regarding COVID-19 rapidly evolves, it is important …

Roc vs. Sux – The CURASMUR Trial

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The debate on the ideal neuromuscular blocking agent for RSI in emergency intubations rages on. In this podcast, we review the latest randomized trial comparing rocuronium with succinylcholine in out-of-hospital patients needing emergency tracheal intubation – The CURASMUR Trial. Emergency medicine airway guru Dr. Ken Butler takes us through the paper and provides his expert opinion on which NMBA you should be …

Identifying and Treating EVALI

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In recent years, the use of e-cigarette and vaping products has sharply risen.  Concomitant with the increased use is an increase in patients presenting with severe respiratory disease associated with these products. In this podcast we review the latest information on the clinical presentation, diagnosis, and treatment of patients presenting with e-cigarette associated acute lung injury (EVALI).  

Critical Care of Cancer Therapy Toxicities

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The number of critically ill cancer patients presenting to the ED is increasing. Though many of these patients are critically ill with conditions directly related to their cancer, some are sick as a result of toxicities from new therapies used to treat their cancer. Dr. Sarah Dubbs joins the podcast to discuss what we NEED to know about these new classes …

Benzodiazepine-Refractory Status Epilepticus – Which Drug is Second-Line?

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Up to one-third of patients with status epilepticus will not respond to benzodiazepines.  Unfortunately, treatment of benzodiazepine-refractory status epilepticus is not well studied.  The longer seizures persist, the worse patients do.  In this podcast, we discuss the results of the recently completed ESETT trial that evaluated three anticonvulsant medications for status epilepticus.

The PrePARE Trial – Do IVFs Prevent Peri-Intubation CV Collapse?

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Up to 25% of critically ill patients who undergo RSI and endotracheal intubation (ETI) may suffer cardiovascular collapse.? Many clinicians administer IVFs during RSI and ETI in hopes of preventing cardiovascular collapse, though this has never been studied…until now.? In this podcast we discuss the results of the recently published PrePARE Trial, as well as provide some thoughts on maximizing …

TTM For Nonshockable Rhythms?

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Current guidelines for post-cardiac arrest management recommend TTM (32C to 36C) for all patients with coma after resuscitation from cardiac arrest. The benefit of TTM is primarily seen in patients who present with a shockable rhythm.  However, nonshockable rhythms are now the most common presenting rhythm in patients with cardiac arrest. The use of TTM in patients with nonshockable rhythms …